Homocysteine Plus - 90 capsules

Allergy Research Group Homocysteine Plus

Methylation support with Setria® glutathione

Homocysteine Plus delivers activated methyl donors and essential cofactors to support healthy methylation, cardiovascular function, and antioxidant balance. This formula provides primary nutrients to facilitate the breakdown of homocysteine into methionine and other metabolites, including coenzyme forms of vitamins B2, B6, folate, and B12, plus Setria® glutathione, zinc, trimethylglycine, and L-serine.

Homocysteine Plus provides broad-spectrum nutritional support for methylation and detoxification pathways that help maintain healthy homocysteine levels. By supplying bioavailable methyl donors and cofactors, this formula supports cardiovascular, neurological, and cellular antioxidant function.

Ingredients

Serving Size: 1 Vegetarian Capsule	Amount/Serving
Riboflavin (as Riboflavin-5-Phosphate)	10 mg
Vitamin B6 (50% as Pyridoxine HCI and 50% as Pyridoxal-5-Phosphate)	30 mg
Folate (as 400 mcg of 5-Methyltetrahydrofolate (from 740 mcg [6S]-5-methyltetrahydrofolic acid, glucosamine salt))	667 mcg DFE
Vitamin B12 (as Methylcobalamin)	400 mcg
Zinc (as Zinc Picolinate)	5 mg
Trimethylglycine	500 mg
L-Serine	100 mg
L-Glutathione (reduced)	50 mg

Other Ingredients: Hydroxypropyl methylcellulose, magnesium stearate, microcrystalline cellulose, silicon dioxide.

Suggested Use

As a dietary supplement, take 1 capsule daily with meals, or as directed by a healthcare practitioner.

Warning: If you are pregnant or lactating, have any health condition or are taking any medication, consult your healthcare practitioner before use.

Storage: Store in a cool, dry place, tightly capped, away from light. Keep out of the reach of children. Use only if safety seal is intact. Variations in product color may occur.

More Info

• L-methylfolate supplies activated folate to support the methionine cycle, bypassing MTHFR polymorphisms.
  
• Methylcobalamin is the bioactive form of vitamin B12, directly participating in methylation reactions required for homocysteine metabolism.
  
• Trimethylglycine (betaine) supports homocysteine-to-methionine conversion via the BHMT pathway, a folate-independent route active in the liver and kidneys.
  
• Serine contributes methyl groups for folate regeneration and promotes cysteine and taurine production for downstream antioxidant support.
  
• Zinc is a cofactor for both methionine synthase and BHMT enzymes that catalyze the remethylation of homocysteine.
  
• Vitamin B6 supports both the folate and transsulfuration pathways, supporting cysteine and glutathione synthesis.
  
• Riboflavin (vitamin B2) is a required cofactor for MTHFR and may enhance folate utilization in individuals with the 677TT genotype.
  
• Glutathione helps balance oxidative stress that may deplete methylation capacity by competing with SAMe synthesis for cysteine.
  
• The homocysteine to methionine cycle contributes to the formation of SAMe (S-adenosylmethionine) SAM-e which is central to creatine, neurotransmitter, and DNA methylation pathways.

Recommended for individuals looking to support healthy methylation, cardiovascular function, or antioxidant balance.

Combines active methyl donors, essential enzyme cofactors, and antioxidant support into a formula designed for comprehensive homocysteine and one-carbon metabolism support.